![]() Keywords: Atrial fibrillation Anticoagulation Reversal of anticoagulation Healthcare resource utilization and costs Idarucizumab Prothrombin complex concentrate Dabigatran Warfarin Introduction When HCRU and costs were examined by cause of reversal and type of bleed, similar trends in hospitalized costs emerged for IDA compared with PCC treatment.Ĭonclusions: This analysis revealed lower HCRU and total hospital costs in patients administered IDA compared with PCC for reversal of oral anticoagulation, though differences in population characteristics and bleeding events were observed that may have contributed to these findings. Median costs per hospitalization for IDA and PCC treatment were $3,277 and $4,424, respectively. Median total costs per hospitalization were $19,357 for IDA patients and $26,920 for PCC patients (P < 0.001). The percentage of patients with an intensive care unit (ICU) admission was lower for IDA patients compared with PCC patients (61.3% vs. Median hospital length of stay was 6 and 7 days for patients who received IDA or PCC (P < 0.001), respectively. IDA patients had lower bleeding and stroke risk assessment scores (HAS-BLED P < 0.001 and CHA 2DS 2-VASc P = 0.014) and lower prevalence of comorbidities compared with PCC patients. Results: Median ages for IDA (n = 1,232) and PCC (n = 4,939) patients were 78 and 74 years (P < 0.001), respectively. ![]() Methods: This retrospective observational study using the Premier Healthcare Database included adult patients aged ≥ 18 years treated with idarucizumab (IDA) or 3- or 4-factor prothrombin complex concentrates (PCC) to reverse the effects of dabigatran or warfarin, respectively, between October 2015 and February 2018. Background: The objective of the study was to describe the healthcare resource utilization (HCRU) and associated costs with hospitalized patients receiving specific versus non-specific oral anticoagulation reversal therapy for life-threatening bleeds and emergency surgeries or urgent procedures. ![]()
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